• Sildenafil Citrate: Proteoform-Driven Insights in cGMP an...

  2025-09-22

  This article explores the unique utility of Sildenafil Citrate as a selective PDE5 inhibitor for dissecting cGMP-mediated signaling pathways, with a focus on proteoform-specific interactions in vascular smooth muscle and cardiovascular research. Integrating recent native mass spectrometry findings, we outline new experimental strategies for studying apoptosis regulation and ERK1/ERK2 phosphorylation modulation.

• Cap 1-Structured Firefly Luciferase mRNA: Enhancing Assay...

  2025-09-19

  Explore how EZ Cap™ Firefly Luciferase mRNA with Cap 1 structure advances molecular biology by enabling highly efficient, stable bioluminescent reporter assays and in vivo imaging. Learn about its technical features, application in modern mRNA delivery, and how it supports rigorous gene regulation research.

• Nonivamide: A TRPV1 Agonist for Targeted Apoptosis and In...

  2025-09-18

  Explore the multifaceted research applications of Nonivamide, a capsaicin analog and TRPV1 receptor agonist, focusing on its dual roles in apoptosis induction and inflammation control within cancer research models.

• Another possible scenario is that the same pathologic proces

  2025-03-03

  

  Another possible scenario is that the same pathologic process has different effects in different people. It might be that the pathway outlined in Fig. 6A is operative in some individuals, but other individuals have a factor Q (which could be genetic or environmental) that blocks the effect of A on T

• In a recent series of studies from our laboratory

  2025-03-03

  

  In a recent series of studies from our laboratory, to characterize the contractile systems within the rat ws3 wall, three conditions were identified that led to detrusor activity: spontaneous micro-contractions, electrical field stimulated (EFS) contractions and muscarinic agonist induced contractio

• hydroxydopamine OHDA is a selective catecholaminergic neurot

  2025-03-03

  

  6-hydroxydopamine (6-OHDA) is a selective catecholaminergic neurotoxin mainly used to generate lesions in the nigrostriatal pathway in rats (Ungerstedt, 1968). The most common use of 6-OHDA is via unilateral injection into the rat medial forebrain bundle (MFB). DA depletion, nigral DA cell loss, and

• In summary we suggest that both cofilin

  2025-03-03

  

  In summary, we suggest that both cofilin and gelsolin are essential factors that regulate sperm capacitation and the acrosomal exocytosis by modulating actin. The relationships between activation/inactivation of cofilin and gelsolin suggest that inhibition of cofilin is important for allowing F-acti

• Furthermore our lab previously reported

  2025-03-03

  

  Furthermore, our lab previously reported that cadmium treatment increased AChE-S and decreased AChE-R variants gene expression, which mediates the cell death observed on basal forebrain cholinergic neurons (Del Pino et al., 2016b). AChE-R decreased expression, which presents a neuroprotective role i

• Additional evidence for a putative role of COXs and

  2025-03-03

  

  Additional evidence for a putative role of COXs and 5-LOX in AD derives from pharmacological studies using inhibitors of these enzymes (for review, see Firuzi and Praticò, 2006). In addition to helping delineate the pathobiological mechanisms of AD, these results raise hope for discovering novel the

• br Identification of the kinase that phosphorylates P

  2025-03-03

  

  Identification of the kinase that phosphorylates P450c17 The first Ser/Thr kinase that phosphorylates P450c17 was identified only recently. Of the 518 kinases in the human ‘kinome’ 278 are Ser/Thr kinases (Manning et al., 2002), but microarrays identified only 145 Ser/Thr kinases in human NCI-H29

• Here we show that the co activation

  2025-03-03

  

  Here, we show that the co-activation of RTKs and non-RTKs is a common trait in treatment-naïve EGFR-mutation-positive NSCLC Hypoxia-inducible factor stabilizer and patients, with AXL and CDCP1 being commonly over-expressed. The combination of gefitinib or osimertinib with the Src/FAK/Janus kinase 2

• br ACL Inhibition Lowering Blood LDL C to Reduce ASCVD

  2025-03-01

  

  ACL Inhibition: Lowering Blood LDL-C to Reduce ASCVD Risk Given its strategic position in the lipid biosynthesis pathway, ACL has been considered an attractive target for lipid-lowering even before statins and their effects on cholesterol homeostasis were elucidated (Box 2). Cells carefully maint

• Production of reactive oxygen species ROS during

  2025-03-01

  

  Production of reactive oxygen species (ROS) during RSV infection is one the important ways that neutrophils can injure the lungs [2], [24], [25]. Lipoxygenases are considered as an important source of producing ROS inside the PRX-08066 [26]. Several studies have indicated that the 12/15-LOX is a pr

• br Materials and methods br Results br Discussion

  2025-03-01

  

  Materials and methods Results Discussion Japanese encephalitis caused by JEV is characterized by cftr inhibitor neuron death. However, the underlying mechanism is not fully understood. We and other researchers have demonstrated that JEV induces apoptosis by ER stress-mediated IRE1/JNK and

• br MADS box proteins in plants a flourishing family In

  2025-03-01

  

  MADS box proteins in plants, a flourishing family In contrast to animals, homeotic genes in plants do not code for homeodomain-containing proteins, but rather, in almost all cases, for MADS domain proteins. The sequencing of the genome of Arabidopsis thaliana revealed more than 100 putative MADS

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