• Some mechanistic experiments performed

  2019-09-02

  Some mechanistic experiments performed in the early 2000s by Ongusaha et al. [78], suggest that DDR1 induction protects Phthalazinone from apoptosis in a p53-dependent manner, and that impairment of DDR1 expression or function leads to a pronounced increase of DNA damage-induced apoptosis.

• The classical ubiquitination pathway

  2019-08-30

  The classical ubiquitination pathway Ubiquitination is an enzymatic process that involves the addition of an ubiquitin protein to a substrate that usually becomes inactivated followed by degradation in the proteasome

• Also our data from this study indicate that

  2019-08-29

  Also, our data from this study indicate that gestational GC exposure altered hematological and hemorheological parameters, however reports exist that altered blood rheological markers are associated with atherosclerosis and CVD (Tzoulaki et al., 2007).

• Discussion In this work we have

  2019-08-28

  Discussion In this work, we have studied the contribution of different pathways to the slow but stable progression of replication forks through DNA damaged by MMS [15].

• Namely the NOESY cross-peaks between

  2019-08-27

  Namely, the NOESY cross-peaks between H-7″ methylene protons ( 4.01 and 4.16) with H-6′ ( 6.76) revealed that H-2 and OH-3 are -orientated, which indicated that the relative configuration of the C2 and C3 substituents as .

• COTSget-based Architectures This

  2019-08-26

  COTSget-based Architectures This section describes how our COTSget-based architectures are defined. We use a design inspired by MDE to build a Domain-Specific Language (DSL) of the architecture, as can be seen in the metamodel of Fig. 3.

• The findings of Qiu et al (2016) represent the

  2019-08-24

  The findings of Qiu et al. (2016) represent the first instance of a Ub-specific mono-ADP-ribosyltransferase, as well as the first documentation of E1/E2 independent ubiquitination.

• Introduction Spending their last days on

  2019-08-23

  Introduction Spending their last days on earth having already lost many cognitive functions remains a major fear of elderly people.

• In this report we established mouse

  2019-08-22

  In this report, we established mouse models suitable for human retinal cell transplantation by introducing phosphodiesterase 6B (Pde6b) mutant allele from retinal degeneration (rd) mouse models into NOG background.

• In mammals NETs contain DNA and antimicrobial

  2019-08-21

  In mammals, NETs contain DNA and antimicrobial proteins composed mainly of nuclear histones, granule-derived neutrophil elastase, myeloperoxidase, lactoferrin, pentraxin, and gelatinase among others [11], [46], [47], [48].

• Some studies have been conducted

  2019-08-20

  Some studies have been conducted on the activities of CYP450 [[28], [29], [30], [31]]. For example, Chen et al. reported that low-dose aspirin induced the in vivo activity of CYP2C19 in healthy subjects [30], Krasniqi et al.

• At 3000ngL−1 DEX did not affect our investigated

  2019-08-19

  At 3000ngL−1, DEX did not affect our investigated parameters, suggesting that DEX is regulated by CYP450 in a biphasic way, a response to xenobiotics that is not uncommon (Heinrichs et al., 1994).

• Discussion Although autophagy is known

  2019-08-17

  Discussion Although autophagy is known to be implicated in the therapeutic effect of DNA alkylating agents such as MNNG [28], [29], [30], the molecular mechanisms underlying autophagy induced by MNNG remain largely elusive.

• Introduction Ubiquitin ligases limit the stability

  2019-08-16

  Introduction Ubiquitin ligases limit the stability and activity of substrates by targeting them for proteasomal-dependent degradation.

• Ample evidence has shown that ET-1 system

  2019-08-15

  Ample evidence has shown that ET-1 system plays a pivotal role in the development of cardiovascular anomalies and pharmacological inhibition of ETA prevents the development of cardiac hypertrophy [[37], [38], [39]].

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