COTSget-based Architectures This

2019-08-26

COTSget-based Architectures This section describes how our COTSget-based architectures are defined. We use a design inspired by MDE to build a Domain-Specific Language (DSL) of the architecture, as can be seen in the metamodel of Fig. 3.

The findings of Qiu et al (2016) represent the

2019-08-24

The findings of Qiu et al. (2016) represent the first instance of a Ub-specific mono-ADP-ribosyltransferase, as well as the first documentation of E1/E2 independent ubiquitination.

Introduction Spending their last days on

2019-08-23

Introduction Spending their last days on earth having already lost many cognitive functions remains a major fear of elderly people.

In this report we established mouse

2019-08-22

In this report, we established mouse models suitable for human retinal cell transplantation by introducing phosphodiesterase 6B (Pde6b) mutant allele from retinal degeneration (rd) mouse models into NOG background.

In mammals NETs contain DNA and antimicrobial

2019-08-21

In mammals, NETs contain DNA and antimicrobial proteins composed mainly of nuclear histones, granule-derived neutrophil elastase, myeloperoxidase, lactoferrin, pentraxin, and gelatinase among others [11], [46], [47], [48].

Some studies have been conducted

2019-08-20

Some studies have been conducted on the activities of CYP450 [[28], [29], [30], [31]]. For example, Chen et al. reported that low-dose aspirin induced the in vivo activity of CYP2C19 in healthy subjects [30], Krasniqi et al.

At 3000ngL−1 DEX did not affect our investigated

2019-08-19

At 3000ngL−1, DEX did not affect our investigated parameters, suggesting that DEX is regulated by CYP450 in a biphasic way, a response to xenobiotics that is not uncommon (Heinrichs et al., 1994).

Discussion Although autophagy is known

2019-08-17

Discussion Although autophagy is known to be implicated in the therapeutic effect of DNA alkylating agents such as MNNG [28], [29], [30], the molecular mechanisms underlying autophagy induced by MNNG remain largely elusive.

Introduction Ubiquitin ligases limit the stability

2019-08-16

Introduction Ubiquitin ligases limit the stability and activity of substrates by targeting them for proteasomal-dependent degradation.

Ample evidence has shown that ET-1 system

2019-08-15

Ample evidence has shown that ET-1 system plays a pivotal role in the development of cardiovascular anomalies and pharmacological inhibition of ETA prevents the development of cardiac hypertrophy [[37], [38], [39]].

Conclusion In this review we have discussed how inhibition

2019-08-14

Conclusion In this review, we have discussed how inhibition of the CK2/CDK5 signaling axis protects WM only when inhibited before ischemia, while inhibition of the CK2/AKT/GSK3β signaling axis protects WM either before or after an ischemic injury in young, aging, and old WM (Fig. 3).

All known vertebrate TRIMs are categorized

2019-08-13

All known vertebrate TRIMs are categorized in 11 distinct subclasses depending on the types of domains present at their carboxyl-terminals (Fig. 3) [29], [35].

Hello world!

2018-07-29