In mammals NETs contain DNA and antimicrobial

2019-08-21

In mammals, NETs contain DNA and antimicrobial proteins composed mainly of nuclear histones, granule-derived neutrophil elastase, myeloperoxidase, lactoferrin, pentraxin, and gelatinase among others [11], [46], [47], [48].

Some studies have been conducted

2019-08-20

Some studies have been conducted on the activities of CYP450 [[28], [29], [30], [31]]. For example, Chen et al. reported that low-dose aspirin induced the in vivo activity of CYP2C19 in healthy subjects [30], Krasniqi et al.

At 3000ngL−1 DEX did not affect our investigated

2019-08-19

At 3000ngL−1, DEX did not affect our investigated parameters, suggesting that DEX is regulated by CYP450 in a biphasic way, a response to xenobiotics that is not uncommon (Heinrichs et al., 1994).

Discussion Although autophagy is known

2019-08-17

Discussion Although autophagy is known to be implicated in the therapeutic effect of DNA alkylating agents such as MNNG [28], [29], [30], the molecular mechanisms underlying autophagy induced by MNNG remain largely elusive.

Introduction Ubiquitin ligases limit the stability

2019-08-16

Introduction Ubiquitin ligases limit the stability and activity of substrates by targeting them for proteasomal-dependent degradation.

Ample evidence has shown that ET-1 system

2019-08-15

Ample evidence has shown that ET-1 system plays a pivotal role in the development of cardiovascular anomalies and pharmacological inhibition of ETA prevents the development of cardiac hypertrophy [[37], [38], [39]].

Conclusion In this review we have discussed how inhibition

2019-08-14

Conclusion In this review, we have discussed how inhibition of the CK2/CDK5 signaling axis protects WM only when inhibited before ischemia, while inhibition of the CK2/AKT/GSK3β signaling axis protects WM either before or after an ischemic injury in young, aging, and old WM (Fig. 3).

All known vertebrate TRIMs are categorized

2019-08-13

All known vertebrate TRIMs are categorized in 11 distinct subclasses depending on the types of domains present at their carboxyl-terminals (Fig. 3) [29], [35].

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2018-07-29