• The present study showed evidence that

  2020-08-10

  

  The present study showed evidence that the AT1 and the ETA receptors were not expressed near or on the plasma membrane as monomers, but also as possibly constitutive dimers and tetramers. For both receptors, the proportion of monomers, dimers and tetramers were unaffected by their respective agonist

• As retinol was not inducing any of the isoforms of

  2020-08-10

  

  As retinol was not inducing any of the isoforms of CYP450 responsible for the bioactivation of paracetamol, we decided to examine retinol\'s effect on renal and hepatic glutathione to determine whether retinol was potentiating hepatotoxicity through a mechanism of glutathione depletion. Studies, uti

• br EBV Infection Epstein Barr virus EBV human herpesvirus

  2020-08-10

  

  EBV Infection Epstein–Barr virus (EBV, human herpesvirus 4) was discovered 50 years ago, when Epstein, Achong, and Barr used electron microscopy to identify viral particles in Burkitt\'s lymphoma cells. It belongs to the lymphocryptovirus (LCV) genus of the gammaherpesvirus subfamily (Fig. 1A). T

• br Authors contribution br Disclosure statement br

  2020-08-09

  

  Authors contribution Disclosure statement Acknowledgements This study has received funding from the Italian Ministry of University and Research (PRIN 2015, grant number 2015373Z39_008) and from the Innovative Medicines Initiative 2 Joint Undertaking under grant agreement No 115797 (INNODIA)

• This article is based on previous research

  2020-08-08

  

  This article is based on previous research work [43] in the field of distributed development of information systems [34]. In that work, the system infrastructure focusing on the three-level data model used in the different layers of our architecture is described. The work presented in this manuscrip

• br Acknowledgements This research was supported by FAPERJ Fu

  2020-08-08

  

  Acknowledgements This research was supported by FAPERJ - Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro (nº E-26/203.551/2015). R.I.S. is a CNPq research fellow. This study was financed in part by Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES).

• The responses to mg mL MCh

  2020-08-08

  

  The responses to 50mg/mL MCh in the control and elastase-induced EG00229 groups did not significantly differ. However, the Raw response to 100mg/mL MCh in the 0.6U elastase-induced emphysema group (0.80±0.07cmH2Os/mL) was reduced when compared to that of the control group (1.51±0.33cmH2Os/mL; p MCh

• Collectively the results presented here provide new insights

  2020-08-07

  

  Collectively, the results presented here provide new insights into ligand binding, clustering, spatial distribution, and phosphorylation of DDR1b and DDR2 in response to soluble collagen I. As depicted in the cartoon of Scheme 1, we postulate a model in which the spatial distribution and assembly of

• A strength of this study is that we used the

  2020-08-06

  

  A strength of this study is that we used the newly developed DGTT, since an effect through changes in gastric emptying is thus bypassed. A limitation of the study, however, is that muscarinic receptors are expressed in many metabolically important tissues (Eglen et al., 1996, Thiele, 2013). A surpr

• RDH belongs to C family of the short chain dehydrogenase

  2020-08-06

  

  RDH10 belongs to 16C family of the short-chain dehydrogenase/reductase (SDRs) superfamily of proteins [12], [13]. Notably, in human genome adjacent to the gene encoding RDH10 on chromosome 8 are located two other genes encoding members of the SDR16C family: retinol dehydrogenase epidermal 2 (RDHE2,

• MDZ is recognized as a relatively specific CYP A probe

  2020-08-06

  

  MDZ is recognized as a relatively specific CYP3A probe drug; decreased AUC of MDZ, increased AUC of its hydroxylated metabolite, OH-MDZ and increased ratio of AUC of OH-MDZ to MDZ are considered as biomarkers of induced CYP3A activity (Urva et al., 2013). As summarized in Table 5, pretreatment with

• Previous limitations in identifying and targeting CRF neuron

  2020-08-06

  

  Previous limitations in identifying and targeting CRF1 neurons in the amygdala were overcome by the development of a BAC transgenic mouse line expressing green fluorescent protein (GFP) in CRF1-containing neurons (Justice, Yuan, Sawchenko, & Vale, 2008). Immunohistochemical examination of GFP expres

• NSC697923 receptor Although the relationship between central

  2020-08-06

  

  Although the relationship between central and peripheral regulation of CRF signaling is yet to be elucidated, an accumulation of findings indicates independent regulation between central and peripheral CRF signaling. For example, i.c.v. administration of CRF to hypophysectomized rats induced locomot

• Here we map the SYNE gene a large

  2020-08-06

  

  Here, we map the SYNE1 gene, a large gene with a complex transcriptional profile, which has been implicated in a variety of diseases. The first group includes muscular dystrophies; Emery–Dreifuss type muscular dystrophy and autosomal recessive arthrogryposis, which are conditions that severely affec

• The varied functionality associated with sodium saccharin

  2020-08-06

  

  The varied functionality associated with sodium saccharin, as a useful chiron, has promoted many attempts for synthesis of a wide range of benzenesulfonamides. Several studies have investigated the analgesic and anti-inflammatory activities of the benzenesulfonamides scaffold attached to a pyrazole

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