• Chronic exposure of cells to cytotoxic drugs can result in

  2022-01-27

  

  Chronic exposure of cells to cytotoxic drugs can result in the selection of multiple phenotypic and genetic changes. Thus, the use of MCF7/VP cells, which were selected for resistance to VP-16, was potentially problematic. However, a thorough characterization of MCF7/VP cells demonstrated that they

• Here we show that lactate activates

  2022-01-27

  

  Here we show that lactate activates the Gi-coupled receptor GPR81, which is exclusively expressed on adipocytes, and that lactate released from adipocytes in response to glucose and insulin mediates insulin-induced antilipolysis by activation of GPR81. Results Discussion Nutrients and their m

• NAD/NADH Quantitation Colorimetric Kit Accumulating studies

  2022-01-27

  

  Accumulating studies revealed a decline of TET1 expression in various cancers including breast, liver, colon, skin, prostate cancers [[36], [37], [38]]. Contrast to these studies, our previous research shows that TET1 is overexpressed in EC and improves the efficacy of chemotherapy in EC, coincide w

• Ubiquitination of GlyRs subunit on plasma membrane

  2022-01-27

  

  Ubiquitination of GlyRs-α1 subunit on plasma membrane has been shown to initiate the receptor Gefitinib australia and subsequent degradation in lysosomes (Buttner et al., 2001). However, the specific E3 ligase responsible for GlyRs-α1 ubiquitination is largely unknown as yet. Also, the functional co

• In patients with type diabetes glucagon

  2022-01-26

  

  In patients with type 2 diabetes glucagon receptor antagonism led lowered fasting glucose however not postprandial glucose levels [9], which may reflect that glucagon may not be of particular importance for the diabetic hyperglycemia upon a meal. Current glucagon receptor antagonists have however be

• In conclusion this is the

  2022-01-26

  

  In conclusion, this is the first study performed in acute limbic seizure models that shows the ability of DAG to dose-dependently attenuate pilocarpine-induced seizures, albeit at a higher concentration as ghrelin (Portelli et al., 2012b). We also establish that DAG's anticonvulsant mechanism of act

• So far only few studies report about GAL in

  2022-01-26

  

  So far only few studies report about GAL in the visual system: GAL has been detected in the cornea of rat (Jones and Marfurt, 1998), mouse (Henken and Martin, 1992) and pig (Stone et al., 1988), and in the uvea of rat (Strömberg et al., 1987), pig (Stone et al., 1988) and cat (Grimes et al., 1994),

• br Acknowledgements We apologize to our

  2022-01-26

  

  Acknowledgements We apologize to our distinguished colleagues whose work has not been cited owing to space limitations. This work was funded by the Italian Association for Cancer Research (AIRC, Milan, Italy, IG 14732 to A.M.); Italian Ministry of University and Education (Finanziamenti per la Ri

• br ACKNOWLEDGMENTS br Introduction Odorant receptors ORs

  2022-01-26

  

  ACKNOWLEDGMENTS Introduction Odorant receptors (ORs) are the largest subfamily of G protein-coupled receptors (GPCRs) and are mainly expressed by olfactory sensory neurons in the nose for the detection of various odorants [1]. However, more recent reports suggest that ORs are also expressed an

• Recent studies have elucidated a profound

  2022-01-26

  

  Recent studies have elucidated a profound role for FFA4 in modulation of metabolism and energy utilization as well as endocrine and immune function, and as a consequence, have thrust FFA4 to the forefront of drug discovery efforts. For example, activation of FFA4 by fatty GSK126 or synthetic ligand

• In our cohort each patient had a

  2022-01-26

  

  In our cohort, each patient had a median of 2 Anti-FXa measurements performed daily and a median of 1 infusion rate change daily to maintain therapeutic unfractionated heparin levels. Previously, several studies have documented that APTT-based protocols lead to more fluctuations in comparison with A

• In addition to indoles two additional structural variants we

  2022-01-26

  

  In addition to indoles –, two additional structural variants were synthesized to explore the synthetic flexibility and structure–activity relationships of this system. The first of these was the homologation of the acetic RGDfK side chain to prepare compound (). The extension of the chain was expe

• Our extensive preliminary data suggest that the loss

  2022-01-26

  

  Our extensive preliminary data suggest that the loss of p300 (and resulting H3K27ac) is related to inorganic arsenic related diseases. Therefore, it may open a new avenue for alleviating the consequence of H3K27ac, for example, via boosting CBP enzymatic activity for at least partially compensating

• br Materials and methods br Results br Discussion Myocardium

  2022-01-26

  

  Materials and methods Results Discussion Myocardium reperfusion injury contributes almost half of myocardial infarct size in myocardial infarction patients, and infarct size is closely correlated with the probability of developing CC-115 failure [1]. Despite this knowledge, myocardial repe

• br Myelin and metabolism In addition to promoting efficient

  2022-01-26

  

  Myelin and metabolism In addition to promoting efficient 1,3-PBIT dihydrobromide australia propagation, myelin is also critical for trophic and metabolic support of axons [56]. To provide metabolites to axons accurately, glia must ‘know’ the metabolic requirements of axons. Could electrical acti

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