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The urinary levels of OHP among the
2022-06-23
The urinary levels of 1-OHP among the exposed workers were higher than those reported for a Brazilian group of charcoal workers (0.07 μmol mol creatinine) exposed to wood smoke (Kato et al., 2004), and for nonsmoking bus drivers (0.19 μmol mol creatinine) and nonsmoking mail carriers (0.11 μmol mol
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In addition researchers studying GPR agonists favor the deve
2022-06-23
In addition, researchers studying GPR119 agonists favor the developing of candidate drugs that are more potent than DPP-4 inhibitors given that the latter are moderate agents in the treatment of DM. Although it KN-92 phosphate synthesis is unclear why Sanofi-Aventis chose to terminate collaboration
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br Introduction Inflammatory bowel diseases IBDs
2022-06-23
Introduction Inflammatory bowel diseases (IBDs) including Crohn's disease and ulcerative colitis (Baumgart and Sandborn, 2012; Beaugerie et al., 2006) are typically characterized by chronic, progressive, and relapsing inflammation of the intestine. Although the exact pathogenesis of IBD is unknow
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In parallel we were also preparing and evaluating
2022-06-23
In parallel, we were also preparing and evaluating other piperidine bioisosteres and modifications to – to further access additional novel intellectual property (IP) space. Modeling work suggested that 4-position homologated piperidines, as well as 3-position homologated azetidines overlapped favora
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br Materials and methods br
2022-06-23
Materials and methods Results Discussion Conclusion Pharmacophore modeling was applied to explore new probable Glo-I inhibitors. Ninety two pharmacophoric models were generated representing diverse types of interaction between co-crystallized ligands and corresponding binding site. The g
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br Computational details and modeling All calculations were
2022-06-23
Computational details and modeling All calculations were performed using the density functional B3LYP [34] method, implemented in Gaussian03 program [35]. The structures of reactants, transition states, intermediates, and products were optimized using the 6-31+G(d) basis set for the H, C, N, O an
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DiscoveryProbe™ Inhibitor Library receptor The occurrence of
2022-06-23
The occurrence of MDR in cancer patients undergoing chemotherapy can be mimicked in the laboratory by culturing cancer DiscoveryProbe™ Inhibitor Library receptor in the presence of chemotherapeutic drugs, thereby enforcing the evolution of acquired drug resistance. This has been described in multip
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Post translational ubiquitination has been shown to regulate
2022-06-23
Post-translational ubiquitination has been shown to regulate a wide range of cellular responses, such as the synaptic trafficking and turnover of neurotransmitter receptors (Rape, 2018). Ubiquitination is also engaged in the modification of protein-protein interaction and intracellular signaling tra
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br Acknowledgments This work was financially
2022-06-23
Acknowledgments This work was financially supported by the National Natural Science Foundation of China (No. 81703451) and the China Postdoctoral Science Foundation Grant (No. 2017M611269). Introduction According to the International League Against Epilepsy (ILAE), epilepsy is generally defin
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Among the various delivery strategies
2022-06-23
Among the various delivery strategies in the field of nano-DDS, developing smart targeted nanocarriers has long been a research focus for pharmaceutical scientists11., 12.. The ideal drug delivery outcome must be precisely delivering the therapeutic agents to their sites of action, especially for an
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br Cell origin The ontogeny of astrocytes in
2022-06-23
Cell origin The ontogeny of astrocytes in vitro has been investigated in detail; Raff et al. (1983) characterised two types of astrocytes: type 1 being fibroblast-like in morphology and poorly labelled with a monoclonal antibody (AB25), whereas type 2 exhibited oligodendrocyte or neuron-like morp
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The developed method was used to
2022-06-23
The developed method was used to quantify RBC membrane transport of the anomers of three monofluorinated analogs of glucose in a modified medium designed to provide stable metabolic properties of the cells over the lifetime of the experiment. This allowed us to evaluate the specific interaction (spe
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The development of immobilization techniques for
2022-06-23
The development of immobilization techniques for β-glucosidase offers a potential way to enable its reuse several times [13]. The aim of immobilization is to trap the enzyme within or on the surface of an insoluble material with retention of its catalytic activity [14]. The immobilization strategy
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br Methods br Results and discussion br Conclusions
2022-06-23
Methods Results and discussion Conclusions A third example of a hexokinase using polyphosphate exclusively as a phosphoryl donor has been identified, this time in mammalian tissues. This is the first polyphosphate utilizing enzyme activity demonstrated in mammalian CID 755673 as far as we a
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Previously we have shown that ghrelin and cannabinoids stimu
2022-06-22
Previously, we have shown that ghrelin and cannabinoids stimulate hypothalamic AMPK activity (Kola et al., 2005). In contrast, both the orexigenic compounds have inhibitory effects on AMPK activity in the liver and visceral fat (Kola et al., 2005). In this study, we were able to reproduce our previo
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