• Introduction Alzheimer s disease AD is a complex neurologica

  2023-08-28

  

  Introduction Alzheimer's disease (AD) is a complex neurological disorder characterized by a progressive dementia resulting from synapse failure (Selkoe, 2002, Tanzi, 2005). The amyloid hypothesis maintains that the pivotal event in AD is the production of amyloid-β (Aβ) peptides following the prote

• In a working group exposed month old transgenic mice mutatio

  2023-08-28

  

  In 2008, a working group exposed 12-month-old transgenic mice (mutation for human amyloid precursor protein expression) and their non-transgenic littermates to isoflurane and halothane for 120min per day for five days. It was concluded that in the transgenic mouse there was overload of amyloid prote

• h2 agonist PL for actin in vitro showed

  2023-08-26

  

  PL for h2 agonist in vitro showed that its profiles, including particular peak and intensity, could determine the length and thickness of an actin filament. Furthermore, we investigated if the PL intensity peak at approximately 340 nm can also be originated from another cytoskeleton filament, such

• br Funding br Introduction The

  2023-08-26

  

  Funding Introduction The interest in the effects of endocrine disrupting chemicals (EDCs) in the aquatic environment continues to increase over the past decade, specifically those that act on steroidogenic pathways. EDCs that include synthetic androgenic and estrogenic compounds can severely a

• This project was funded by the University of

  2023-08-26

  

  This project was funded by the University of the Philippines Diliman through the Natural Sciences Research Institute with grant No. CHE-09-2-02. Introduction There is compelling evidence for an anti-inflammatory effect of 12- and 15-lipoxygenases through the generation of lipid mediators involve

• Apelin is a peptide hormone and an endogenous ligand for

  2023-08-26

  

  Apelin is a peptide hormone and an endogenous ligand for a G protein-coupled receptor named APJ [7], [8], and apelin and APJ are widely expressed in human organs including hypothalamus, heart, lungs, kidneys, adipose tissue, muscles, and others [9]. Apelin is initially synthesized as a 77-amino-acid

• There is a delicate balance between

  2023-08-26

  

  There is a delicate balance between ROS generation and scavenging by the protective antioxidant defenses in the cell. Antioxidant systems present in the motilin receptor include enzymes like superoxide dismutase (SOD), catalases, glutathione peroxidases (GPxs) and peroxiredoxins (PRxs) (Fig. 3) [38

• Apelin is a bioactive peptide and

  2023-08-26

  

  Apelin is a bioactive peptide and endogenous ligand for the APJ receptor (APLNR), a member of the G protein coupled receptor family that shares a similar sequence as the angiotensin type-1 receptor (AT1) [5]. Early studies demonstrated that the apelin/APLNR receptor axis plays a significant role in

• To further address the mechanism of Didox

  2023-08-26

  

  To further address the mechanism of Didox’s suppressive effects on mast cell activation, FceRI receptor hippo pathway and downstream transcription factor induction were assessed. We found that Didox had no effect on FceRI surface expression, and thus concluded that Didox effects must be occurring d

• Many naphthoquinone derivatives have been previously obtaine

  2023-08-26

  

  Many naphthoquinone derivatives have been previously obtained from fungi in the genus Fusarium isolated from various sources, F. oxysporum from the root of citrus (Nagia and El-Mohamedy, 2007), Fusarium sp. (No. b77) from the mangrove plant (Shao et al., 2010), F. solani and F. oxysporum from fibrou

• br HIF Signaling in AA Therapy Resistance

  2023-08-26

  

  HIF-α Signaling in AA Therapy Resistance An important result emerging from Phase 3 clinical trials testing AA therapies is improvement of progression-free survival (PFS) that is not accompanied by enhanced overall survival (OS) [26]. This dichotomy has been attributed to mechanisms of acquired re

• br Concluding remarks br Conflict

  2023-08-26

  

  Concluding remarks Conflict of interest Acknowledgment This work was supported by the H.E.B. Endowed Chair in Marine Science (to P.T.) and University of Texas Marine Science Institute endowment-supported scholarships (to A.C). Introduction Disorders of sex development (DSD) are defined

• br Depletion of serum amino acids Currently the only antican

  2023-08-26

  

  Depletion of serum amino acids Currently, the only anticancer agents that directly target amino PF-03084014 receptor metabolism are bacterial l-asparaginases (from Escherichia coli and Erwinia chrysanthemi), which are FDA-approved for treatment of pediatric and adult ALL. A potential complicatio

• A disfun o cognitiva p s operat ria uma s

  2023-08-26

  

  A disfunção cognitiva pós‐operatória é uma síndrome perioperatória bem reconhecida, consequência da anestesia e cirurgia cuja causa exata permanece por esclarecer. De que forma Diclofenac disfunção cognitiva pós‐operatória e a doença de Alzheimer podem estar ligadas permanece uma questão em estudo.

• Interestingly hypoxia and an enhanced Warburg effect ultimat

  2023-08-26

  

  Interestingly, hypoxia and an enhanced Warburg effect ultimately lead to increased lactate production. The accumulation of lactate results in an acidic tumor microenvironment, which induces local inflammation. Lactate also promotes the polarization of macrophages that express immunosuppressive argin

14480 records 286/966 page Previous Next First page 上5页 286287288289290 下5页 Last page