• The zebrafish Danio rerio is a popular model organism for

  2023-11-21

  

  The zebrafish (Danio rerio) is a popular model organism for virtually any biological function of vertebrates, and has, therefore, received a wide distribution in particular in developmental biology and toxicology (Strähle et al., 2012). With respect to AChE, the zebrafish has, e.g., been identified

• br Antioxidative stress and anti inflammation Oxidative stre

  2023-11-21

  

  Antioxidative stress and anti-inflammation Oxidative stress is a major cause of reduced endothelial NO bioavailability in hypertension, and inflammatory response is thought to play an important role in these processes (Blake and Ridker, 2001, Landmesser et al., 2006). Reactive oxygen species (ROS

• pde inhibitors br Introduction Stroke is a devastating condi

  2023-11-21

  

  Introduction Stroke is a devastating condition that causes cognitive and motor dysfunction, neurodegenerative diseases and even acute death, and is a leading cause of mortality and morbidity worldwide (Chen et al., 2014a, Wang et al., 2016). Thus, exploration or identification of novel therapeuti

• Imatinib is a well known anticancer drug used in Chronic

  2023-11-21

  

  Imatinib is a well-known anticancer drug used in Chronic Myeloid Leukemia (CML) against the altered expression/activity of tyrosine kinase resulting from the fusion of BCR-ABL in leukemic blasts. It has been demonstrated that Imatinib can induce autophagy in BCR-ABL expressing HQNO (K562 cell line a

• GABAB receptor is associated with brain and behavioral disea

  2023-11-21

  

  GABAB receptor is associated with xpo 1 and behavioral diseases, including epilepsy, spasticity, anxiety and neuropathic pain (Bettler et al., 2004, Bowery et al., 2002, Froestl, 2010). Baclofen, a clinical drug and selective GABAB receptor agonist, is used to treat muscle spasticity in patients wit

• Expression subcellular localization transcriptional activity

  2023-11-21

  

  Expression, subcellular localization, transcriptional activity and protein stability of Foxo are regulated by proteins such as STAT3, PKB, JNK and AMPK (Sun et al., 2017; Zhang et al., 2011). STAT3 is a member of the signal transducer and activator of transcription (STAT) protein family that plays c

• Introduction Antimicrobial resistance is a growing health th

  2023-11-21

  

  Introduction Antimicrobial resistance is a growing health threat worldwide that has been associated with incorrect prescription and overuse of Capsaicin [1]. Considering that physicians play a central role in antibiotic usage, a better understanding of their prescribing behaviours and their knowle

• br Eprosartan The AT R antagonist eprosartan is

  2023-11-21

  

  Eprosartan The AT1R antagonist eprosartan is approved for the treatment of essential Gastrodin and may be administered using a convenient once-daily regimen. The drug is a well-tolerated and effective antihypertensive agent with benefit in the secondary prevention of cerebrovascular events, inde

• Most of the latest http www apexbt com media diy

  2023-11-21

  

  Most of the latest works reported that in human hair follicle AR expression is restricted to DPC and is not found in the outer root sheath (ORS), hair bulb or bulge (Itami et al., 1995a, Jave-Suarez et al., 2004, Kariya et al., 2005, Pelletier et al., 2004, Thornton et al., 2003). DPC derived from b

• br Materials and method br Result

  2023-11-20

  

  Materials and method Result and discussion Conclusion Acknowledgments This work is partly supported by the University Research Committee (URC) of the Senate of The Federal University of Technology, Akure. The authors thanked IFS for the funds (F/4449 1F and F/4449-2F) used to purchase th

• mitotic inhibitor The ARHL locus ahl that

  2023-11-20

  

  The ARHL locus (ahl) that contributes to the hearing loss in the C57BL/6J mouse has been mapped to chromosome 10 (Erway et al., 1993, Johnson et al., 1997). It has been shown that strains susceptible to early onset ARHL carry a specific mutation in the cadherin 23 gene (Cdh23), which encodes a compo

• A high throughput small molecule ACK biochemical inhibition

  2023-11-20

  

  A high-throughput small molecule ACK1 biochemical inhibition screen was performed in-house and led to the identification of 1μM inhibitor furanopyrimidine (). Further binding studies found Gentamycin Sulfate to be both ATP-competitive and reversible. Early structure-activity relationship (SAR) wo

• Numerous studies have reported high glutamate levels in the

  2023-11-20

  

  Numerous studies have reported high glutamate levels in the brains of patients with depression, indicating that the glutamate system plays a crucial role in depression (Sanacora et al., 2004; Kendell et al., 2005; Hashimoto et al., 2007). Furthermore, several clinically effective antidepressant drug

• In conclusion we have produced some highly potent inhibitors

  2023-11-20

  

  In conclusion, we have produced some highly potent inhibitors of P450 in comparison to the standard 2-Palmitoylglycerol KTZ. Also, due to the limited specificity of these compounds against lyase in comparison to the 17α-OHase component, these compounds would be expected to have a major impact on cor

• br Studies in zebrafish vascular and

  2023-11-20

  

  Studies in zebrafish: vascular and neural development and the regulation of left–right asymmetry Zebrafish embryos represent an excellent model system to examine vertebrate vascular development. Major advantages of the zebrafish system include its genetic tractability, small size, external fertil

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