• The discovery of acetylsalicylic acid aspirin

  2024-02-19

  

  The discovery of acetylsalicylic Sanguinarine chloride (aspirin) in 1897 paved the way for the development of classical NSAIDs as first-line therapeutics for anti-inflammatory, anti-pyretic and analgesic therapy. Large efforts have been made in the following decades to improve the efficacy and in p

• Pompe disease is accompanied by the

  2024-02-19

  

  Pompe disease is accompanied by the deficiency of the lysosomal α-1,4-glucosidase that makes the GSA 10 unable to hydrolyze glycogen to glucose, thereby resulting in the accumulation of glycogen in lysosomes, especially in skeletal muscles and cardiac tissues. This accumulation results in the struc

• Based on currently available knowledge autophagy

  2024-02-19

  

  Based on currently available knowledge, autophagy supports adipocytes development and differentiation. In animals with specific skeletal muscle colorimetric assay of Atg7, reduced adipogenesis was shown. In rodents, autophagy was decreased in adipose tissue of animals fed with high-fat diet (HFD).

• Mechanistically it was soon realized that in

  2024-02-19

  

  Mechanistically, it was soon realized that in undead cells, Dronc promotes the activation of Jun-N-terminal kinase (JNK) signaling as the major inducer of AiP [25], [28] (Fig. 2B,C). However, it has been unknown for a long time how active Dronc promotes JNK signaling. Recently, it was reported that

• Sulfaphenazole br Natriuretic peptides and neprilysin Left v

  2024-02-09

  

  Natriuretic peptides and neprilysin Left ventricular systolic function, most commonly due to myocardial damage as a consequence of coronary artery disease, hypertension or both, and leading to sustained, pathological activation of the renin angiotensin Sulfaphenazole system (RAAS) and sympatheti

• Perhaps the first evidence of AMPKs therapeutic ability

  2024-02-09

  

  Perhaps the first evidence of AMPKs therapeutic ability in DM1 came from Thomas Cooper’s laboratory where they demonstrated that insulin-independent glucose uptake was unaffected in human DM1 muscle SCR7 pyrazine treated with MET, an AMPK activator and first-line therapy for type 2 diabetes mellitu

• Calcium entry through postsynaptic NMDARs activates intracel

  2024-02-09

  

  Calcium entry through postsynaptic NMDARs activates intracellular signaling cascades including Ca2+/calmodulin (CaM)-dependent protein kinase II (CaMKII) and calcineurin. The spatiotemporal abundance of this Ca2+/CaM complex determines the direction of synaptic plasticity, resulting in LTP (Malinow

• Volatile esters are important to wine quality and to

  2024-02-09

  

  Volatile esters are important to wine quality and to fresh berry grape flavor, especially in fox grapes (V. labrusca) [16]. Volatile esters such as Z-3-hexyl acetate can be found in V. vinifera ‘Cabernet Sauvignon’ berries albeit at low levels and their accumulation diminishes to below detection lev

• Constitutive tyrosine kinase activity of BCR ABL fusion gene

  2024-02-09

  

  Constitutive tyrosine kinase activity of BCR/ABL fusion genes causes uncontrolled cell growth and is also thought to be responsible for a variety of changes in normal cellular functions like differentiation, adhesion, migration and apoptotic response in CML. Therefore it is important to know the exp

• Our co IP data show that HT A

  2024-02-09

  

  Our co-IP data show that 5HT1A or 5HT2A receptors do not heterodimerize with mGluR1α receptors. Given that both 5-HT and mGlu receptors are GPCRs and produce anxiolytic effects, a degree of cooperativity via a functional cross-talk may still exist between these receptors [11]. In addition to the fun

• Despite functional studies demonstrating the role

  2024-02-09

  

  Despite functional studies demonstrating the role of 5-HT in ureteral contractility, the source of endogenous 5-HT in the ureter is unclear. Since 5-HT-containing enterochromaffin cells, which are present in the gastrointestinal tract, could not be found in the ureter (Nocito et al., 2007, Ripoche,

• Serum soluble sCD is a shedding product from the

  2024-02-09

  

  Serum soluble sCD21 is a shedding product from the ectodomain of membrane CD21 after B cell activation (Masilamani et al., 2003, Masilamani et al., 2004a, Masilamani et al., 2004b, Grottenthaler et al., 2006, Hoefer et al., 2008), which resembles the ligand-binding capacity of intact CD21 (Wu et al.

• As described in the introductory section the rotifer nervous

  2024-02-09

  

  As described in the introductory section, the rotifer nervous system would be capable to transmit Quercitrin synthesis in throughout its neural pathways. In addition, Clément and Amsellem (1989) and Kotikova et al. (2001) suggested acetylcholine to be important for the functioning of rotifer muscle

• It has been reported that

  2024-02-09

  

  It has been reported that leukotrienes and their receptors, e.g. the cysteinyl leukotriene receptor 1 (CysLT1) may promote Naringin injury (Ding et al., 2007) and that increased 5-LOX expression and activity lead to production of brain-toxic molecules (Khan et al., 2010). However, differential effe

• The role of DHT in early teleost embryogenesis

  2024-02-09

  

  The role of DHT in early teleost embryogenesis is not entirely clear or established, however additional studies that treat fish embryos to DHT or to specific srd5a inhibitors at critical stages of development (i.e. prior to sex differentiation) will shed light on the early functions of this androgen

14518 records 193/968 page Previous Next First page 上5页 191192193194195 下5页 Last page